Originally settled in the late 18th century, the area was a destination for those seeking fortune in the timber industry. A number of saw mills were built in what is now the city limits and operated through the 1800’s until the area’s pine forests were depleted. At the turn of the 20^th century and the advent of the automobile industry, Marysville became home to several automobile manufacturers and automobile parts makers including C. H. Wills & Company which manufactured the Wills Ste. Clair automobile until 1926 and Chrysler which still functions today as an automobile parts manufacturer.

Marysville’s industrial economy remains very developed in the 21^st century. While the city’s industrial base still is heavily vested in the automobile parts industry, it has grown and diversified itself to include: Intertape Polymer Group, manufacturers of tape and package-sealing materials; Pregis Performance Products, LLC, makers of Polyethylene Foam products; Marysville Hydrocarbon, LLC, a propane and butane storage facility and; Marysville Ethanol, producers of ethanol.  Major employers in the city include the above-mentioned companies along with U.S. Customs and Border Patrol and Meijer, a regional grocery chain.

Marysville became a Charter City in 1965.

City Hall is located at 1255 Delaware Avenue in Marysville and is open Monday through Friday from 8 a.m. to 4:30 p.m.